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Epidemiological data indicate an association between periodontitis and obesity.

The biological mechanisms of this relationship remain unclear. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

A cross-sectional study was conducted to evaluate the relationship between periodontitis and the common systemic inflammatory markers in 32 morbidly obese patients recruited in a Clinical Nutrition department. Epidemiological data indicate an association between periodontitis and obesity.

Periodontal condition was evaluated using pocket depth (PD) measurement, a classical clinical marker of ongoing periodontitis. Contributed reagents/materials/analysis tools: JML CP C. The biological mechanisms of this relationship remain unclear.

The underlying biological mechanism involves local periodontal inflammation that may increase the levels of systemic inflammatory mediators, thereby promoting atherosclerosis and insulin resistance [12].

A potential link between obesity and periodontitis has also been shown [13], [14], [15].

Adjusted logistic regression analysis indicated that the severity of periodontitis was associated with the plasma level of orosomucoid (p Periodontitis comprises a group of multifactorial inflammatory diseases that affect the periodontium, i.e.

Patients having rheumatoid arthritis, malignant disease, or a past history of cardiovascular disease were excluded from the study.

To date, no study has specifically focused on the periodontal status of morbidly obese subjects (Body Mass Index ≥40 kg/m).

We hypothesized that periodontitis in morbidly obese subjects could alter the profile of inflammatory mediators.

Before surgery, these patients underwent a periodontal screening at the Department of Odontology, Bretonneau Hospital (Paris, France).

All patients, referred between September 2007 and July 2008, were considered for inclusion.